approaches of gene therapy slideshare

The SlideShare family just got bigger. It is an artificial method that introduces DNA into the cells of the human body. Weve updated our privacy policy so that we are compliant with changing global privacy regulations and to provide you with insight into the limited ways in which we use your data. by gene targeting methods based on homologous recombination); or at the RNA transcript level (e.g. Clipping is a handy way to collect important slides you want to go back to later. Development of an ex vivo Gene Therapy for Frontotemporal . Slideshows for you (19) Gene therapy in clinical applications Dr. Ishan Y. Pandya GENE THERAPY: PRINCIPLES, PROBLEMS AND PROSPECTS Albert Swat Gene therapy.. Dr.Padmesh Dr Padmesh Vadakepat Gene therapy Chunu Darnal Gene therapy - a Powerpoint Presentation David Dy Gene therapy Akshaya Akshaya Advancements of medical biotechnology in gene therapy The SlideShare family just got bigger. You can read the details below. Gene therapy is a technique which involves the replacement of defective genes with healthy ones in order to treat genetic disorders. Tap here to review the details. safavieh leather woven chair; escape from tarkov poison. It was a dream of the researchers to replace the defective genes with good ones and cure the genetic disorders. The technique of ex vivo gene therapy involves the following steps (Fig. saloon or salon pronunciation. Instant access to millions of ebooks, audiobooks, magazines, podcasts and more. Transplant the modified cells to the patient. 3. The SlideShare family just got bigger. Gene therapy types advantags disadvantages, DNA lipofection - Efficiency in invitro and invivo transfection, Irresistible content for immovable prospects, How To Build Amazing Products Through Customer Feedback. Epigenetic therapy works by altering cell expression. Gene delivery , Gene therapy . Clipping is a handy way to collect important slides you want to go back to later. Two approaches for correcting single-gene defects are gene therapy such as is discussed in Section and the system. Gene therapy In gene therapy, your stem cells are changed by altering part of your genes. Dr D Y Patil College of Pharmacy Akurdi Pune. Defective gene Incorrect sequence of bases Inability of a gene to code for the expression of a particular polypeptide Gene-transfer approaches are based upon the simple concept that if a disease is due to a recessive loss-of-function mutation in a single gene, then adding back the wild-type gene should. Gene TherapyGene Therapy Nowadays gene therapy opened doors for dentistry. Check the source www.HelpWriting.net This site is really helped me out gave me relief from headaches. People with SCID lack virtually all immune protection from bacteria, viruses, and fungi. A gene can be delivered to a cell using a carrier known as a vector. The most common types of vectors used in gene therapy are viruses. Gene therapy has now become a relatively simple process. Now customize the name of a clipboard to store your clips. No problem. Gene therapy is an experimental treatment that involves introducing genetic material into a persons cells to fight or prevent disease. Biotechnology 2. We've encountered a problem, please try again. Clipping is a handy way to collect important slides you want to go back to later. The approach uses the Fos gene, whose expression is up-regulated by neuronal activity, including seizures, to control the Kcna1 gene, which encodes an inhibitory gene that quiets neuronal activity. Direct cell killing is possible if the inserted genes are expressed to produce a lethal toxin (suicide genes), or a gene encoding a prodrug is inserted, conferring susceptibility to killing by a subsequently administered drug. APIdays Paris 2019 - Innovation @ scale, APIs as Digital Factories' New Machi Mammalian Brain Chemistry Explains Everything. Somatic gene therapy (two categories) vivo (where cells are modified outside the body and then transplanted back in again) in . APIdays Paris 2019 - Innovation @ scale, APIs as Digital Factories' New Machi Mammalian Brain Chemistry Explains Everything. It aims to target the cause of disease on a genetic level. The viruses used in gene therapy are altered to make them safe, although some risks still exist with gene therapy. You can read the details below. Gene delivery and gene therapy . 1. A variety of approaches target the blood stem cells to reduce your symptoms of sickle cell disease. Gene therapy is the application of genetic engineering techniques to alter or replace defective genes. Gene therapy was once considered a fantasy (imaginary). Free access to premium services like Tuneln, Mubi and more. Researchers created liposomes 25 nanometers across that can carry therapeutic DNA through pores in the nuclear membrane 2002 Introduction of gene therapy, its types and major Ky aspects. Recent advances in "gene therapy" and "gene therapy-based approaches" have been quite substantial, which include delivery vectors, gene engineering technologies, application to chimeric antigen receptor (CAR) T cell therapy, and oncolytic viruses. Short Answer. We've updated our privacy policy. Somatic cell gene therapy is when therapeutic genes are transferred to a patient's somatic cells. delhi super league registration. The nonmutated gene encodes a functional protein that the patient would otherwise be unable to produce. Some cell therapies are routine, like blood transfusions. Severe Combined Immune Deficiency (SCID) was one of the first genetic disorders to be treated successfully with gene therapy, proving that the approach could work. Gene therapy attempts to correct genetic abnormalities by introducing a nonmutated, functional gene into the patient's genome. Introduce the therapeutic gene to correct gene defect. If disease cells display a novel gene product or inappropriate expression of a gene (as in the case of many cancers, infectious diseases, etc. I can advise you this service - www.HelpWriting.net Bought essay here. Isolate cells with genetic defect from a patient. It involves the . Enjoy access to millions of ebooks, audiobooks, magazines, and more from Scribd. The first gene therapy was successfully accomplished in the year 1989. This technique is widely used to treat those defective genes which contribute to disease development. We've encountered a problem, please try again. Activate your 30 day free trialto continue reading. Bridging the Gap Between Data Science & Engineer: Building High-Performance T How to Master Difficult Conversations at Work Leaders Guide, Be A Great Product Leader (Amplify, Oct 2019), Trillion Dollar Coach Book (Bill Campbell). Allele-specific inhibition of expression may be possible in some cases, permitting therapies for some disorders resulting from dominant negative effects. Grow the cells in culture. This technique has the potential to treat thalassaemia, cystic fibrosis and some cancers. The AAV-based gene therapy approach reduced neuronal excitability by harnessing biochemical signals that increase in response to seizure-related activity, leading to a persistent anti-epileptic . However, the first clinical trials ended when the viral vector triggered leukemia (a type of blood cancer) in some patients. A new gene therapy approach repaired errors in messenger RNA derived from defective genes. One approach is gene-modified cell therapy, which removes the cells from the patient's body, then a new gene can be introduced or a faulty gene can be corrected. Suitable for diseases such as cancer that can be treated by destroying certain groups of cells. Tap here to review the details. Several promising gene-therapy treatments are under development for cancer. Gene therapy was once considered a fantasy (imaginary). Basically gene therapy is an intracellular delivery of genomic materials (transgene) into specific cells to generate a therapeutic effect by correcting an existing abnormality or providing the cells with a new function. APIdays Paris 2019 - Innovation @ scale, APIs as Digital Factories' New Machi Mammalian Brain Chemistry Explains Everything. It is used to grow new teeth, bone repair and teeth regeneration. It was a dream of the researchers to replace the defective genes with good ones and cure the genetic disorders. The study was designed as a basic qualitative approach. terapi gen kelainan genetik genetic disorders treatment, Genetherapypresentation 120220051948-phpapp02, Irresistible content for immovable prospects, How To Build Amazing Products Through Customer Feedback. The treatment, called T-VEC, uses a virus that has been modified so that it will (1) not cause cold sores; (2) kill only cancer cells, not healthy ones; and (3) make signals that attract the patient's own immune cells, helping them learn to recognize and fight cancer cells throughout the body. Gene therapy is a strategy used to treat disease by correcting defective genes or modifying how genes they are . Instant access to millions of ebooks, audiobooks, magazines, podcasts and more. Strategies of gene therapy. Now customize the name of a clipboard to store your clips. Activate your 30 day free trialto continue reading. The CRISPR-Cas 9 approach can be used in embroys to delete the genes for malfunctioned proteins. Free access to premium services like Tuneln, Mubi and more. Below are some gene therapy success stories. Germline gene therapy has been achieved experimentally in animals but not in humans. INTRODUCTION. Stem cells containing the working ADA gene were injected into Andrew's blood. Valrox (valoctocogene roxaparvovec or BMN 270) is a gene therapy being developed by Biomarin to treat hemophilia A. With in vivo gene therapy, new genes are inserted directly into your body. AI and Machine Learning Demystified by Carol Smith at Midwest UX 2017, Pew Research Center's Internet & American Life Project, Harry Surden - Artificial Intelligence and Law Overview, No public clipboards found for this slide. Weve updated our privacy policy so that we are compliant with changing global privacy regulations and to provide you with insight into the limited ways in which we use your data. Blood was removed from his mother's placenta and umbilical cord immediately after birth, to acquire stem cells. Gene delivery and gene therapy . Learn faster and smarter from top experts, Download to take your learnings offline and on the go. MLD is short for metachromatic leukodystrophy accumulation of fats called sulfatides in cells. Activate your 30 day free trialto unlock unlimited reading. Blockchain + AI + Crypto Economics Are We Creating a Code Tsunami? 2. An example of this approach is CAR-T cell therapy . Now customize the name of a clipboard to store your clips. Nucleic acid based therapeutic drug delivery system, POTENTIAL TARGET DISEASES FOR GENE THERAPY, Gene Therapy;Boon Or Adversary To Humanity, Gene therapy types advantags disadvantages, Advancements of medical biotechnology in gene therapy, St.Xavier's College , Palayamkottai - 627 002, Irresistible content for immovable prospects, How To Build Amazing Products Through Customer Feedback. Weve updated our privacy policy so that we are compliant with changing global privacy regulations and to provide you with insight into the limited ways in which we use your data. Department of Chemistry theoretically, this approach should be highly effective in Explain why the approach can potentially provide more complete restoration of normal tissue function than gene therapy. Viji Gene therapy: short introduction Devang Parikh Gene therapy Sharadha M Gene therapy Annie Mirza ADA-SCID gene therapy (Aiuti at al. The modified cells are then put back into the body. AI and Machine Learning Demystified by Carol Smith at Midwest UX 2017, Pew Research Center's Internet & American Life Project, Harry Surden - Artificial Intelligence and Law Overview, No public clipboards found for this slide. Click here to review the details. APIdays Paris 2019 - Innovation @ scale, APIs as Digital Factories' New Machi Mammalian Brain Chemistry Explains Everything. Gene therapy is the use of genetic material to treat or prevent disease. Blockchain + AI + Crypto Economics Are We Creating a Code Tsunami? (A new tool to cure human diseases) Currently, autophagy is one of the most consensual therapeutic targets for neurodegenerative diseases and cancer, both through gene therapy and pharmacological approaches. 1 Creating a working gene. Stem Cells And Clinical Applications. Anti-sense nucleic acids to block the production of rejection associated molecules such as adhesion molecules. The new DNA usually contains a functioning gene to correct the effects of a disease-causing mutation. entj female and istp male. Activate your 30 day free trialto unlock unlimited reading. Click here to review the details. 8-10 the 2011;17 (24):2558 . Biological approaches to bone regeneration by gene therapy . AI and Machine Learning Demystified by Carol Smith at Midwest UX 2017, Pew Research Center's Internet & American Life Project, Harry Surden - Artificial Intelligence and Law Overview, No public clipboards found for this slide. Select the genetically corrected cells (stable trans-formants) and grow. Both methods have risks and side effects associated with them. Gene Therapy Sebastian Misztal was a patient in a hemophilia gene therapy trial in 2011. Genes that are important in preventing graft rejection can be introduced (e.g. INTRODUCTION Gene therapy is when DNA is introduced into a patient to treat a genetic disease. Genome editing technologies allow genetic material to be added, removed, or altered at precise locations in the genome. These are the cells of an organism other than sperm or eggs cells, e.g., bone marrow cells, blood cells, skin cells, intestinal cells. Activate your 30 day free trialto continue reading. Activate your 30 day free trialto unlock unlimited reading. 4. Hence, in new secondary science k to 12 curriculum, the students are exposed to spiral progression approach, wherein the four areas, namely Earth Science, Biology . Any modification and any effects are restricted only to that patient and are not inherited by future generations. Blockchain + AI + Crypto Economics Are We Creating a Code Tsunami? 5. Gene therapy techniques allow doctors to treat a disorder by altering a person's genetic makeup instead of using drugs or surgery. Advances in biochemistry and molecular biology have helped to understand the genetic basis of inherited diseases. Alternatively, selectively lytic viruses can be used. Leber congenital amaurosis is an eye disorder that primarily affects the retina. The Forefront of Medicine In this review we will describe advances suggesting that the LSDs may be some of the most amenable diseases to treat by gene therapy based approaches. In this review, promising and new gene therapy approaches and clinical studies are briefly discussed to highlight important future directions of preclinical and clinical efforts. Instant access to millions of ebooks, audiobooks, magazines, podcasts and more. 1. For four years T cells (white blood cells), produced by stem cells, made ADA enzymes using the ADA gene. The in vivo gene therapy or viral vector-mediated gene therapy is a good option for treating diseases like Parkinson's disease, Alzheimer's disease, and brain tumors. [] Different types of gene delivery systems may be applied in gene therapy to restore a specific gene function or turning off a special gene(s). The SlideShare family just got bigger. The term gene therapy is a broad one: it encompasses many different strategies, all of which are designed to overcome or alleviate disease by a procedure in which genes, gene segments or oligonucleotides are introduced into the cells of an affected individual. Bridging the Gap Between Data Science & Engineer: Building High-Performance T How to Master Difficult Conversations at Work Leaders Guide, Be A Great Product Leader (Amplify, Oct 2019), Trillion Dollar Coach Book (Bill Campbell). Two herpes vaccine candidates, RVx201 and RVx202 have been shown to be safe in a new pre-clinical study by researchers at the Department of Population Health Sciences, Virginia Tech, and the University of Oklahoma Health Sciences Center. In vivo gene transfer is necessary when cultured cells cannot be re-implanted in patients effectively. We've encountered a problem, please try again. Learn more about the basics of gene therapy, the potential for this growing field of research, along with the challenges and risks still needing to be investigated. Bridging the Gap Between Data Science & Engineer: Building High-Performance T How to Master Difficult Conversations at Work Leaders Guide, Be A Great Product Leader (Amplify, Oct 2019), Trillion Dollar Coach Book (Bill Campbell). However, in addition to immunogenic effects of viruses, the random integration of viral genes may damage the genome, affect the cell phenotype or even cause . Slideshows for you (20) Gene therapy- An introduction & Concept Dr. Sharad Chand Gene therapy RAM PRAKASH POTENTIAL TARGET DISEASES FOR GENE THERAPY MUSTAFIZUR RAHMAN Gene therapy TathagatSah Gene therapy vedprakashpanda2 Gene therapy PV. Click here to review the details. 13.2). Weve updated our privacy policy so that we are compliant with changing global privacy regulations and to provide you with insight into the limited ways in which we use your data. Researchers are studying gene therapy for a number of diseases, such as severe combined immuno-deficiencies, hemophilia, Parkinson's disease, cancer and even HIV, through a number of different approaches (see video: 'Gene Therapy a new tool to cure human diseases'). Weve updated our privacy policy so that we are compliant with changing global privacy regulations and to provide you with insight into the limited ways in which we use your data. approaches involved in gene therapy germ line gene therapy: where germ cells (sperm or egg) are modified by the introduction of functional genes, which are integrated into their genome. The results revealed that pre-service science teachers made decisions by using one (rationalistic, emotive, or intuitive) or more informal The basics of the process are the identification of the gene in question, duplication of that gene, and insertion of the gene into the human genome needing the gene (CIS) . Good luck! by removing the viral DNA and using the virus as a vehicle to deliver the therapeutic DNA. 1. Ex vivo gene therapy involves removing cells from your body, modifying them, and placing them back into your body. However, poor cellular uptake and instability of DNA in the physiological milieu limits its therapeutic potential, hence a vector which can protect and efficiently transport DNA to the target cells must be developed. Blockchain + AI + Crypto Economics Are We Creating a Code Tsunami? Genome editing is a newer technique that may potentially be used for gene therapy. Injections of the ADA enzyme were also given weekly. The technology is still in its infancy, but it has been used with some success. Free access to premium services like Tuneln, Mubi and more. Slideshows for you (20) Gene therapy ppt Nurul Miza Shasheiha Gene therapy By, DR Ganesh Chalise,NAMS Ganeshbchalise Gene Therapy Asma Hossain Gene theapy Monirul Islam Shohag Gene therapy Nawfal Aldujaily Gene Therapy by Anupam Dwivedi (MS) ssshammi1234 GENE THERAPHY Dr D Y Patil College of Pharmacy Akurdi Pune. by using particular types of therapeutic ribozymes or therapeutic RNA editing). An example of this approach is CAR-T cell-based gene therapy. Transcription II- Post transcriptional modifications and inhibitors of Transc Nucleic acid based therapeutic delivery system. The efcient transfer of the genetic material into a cell is necessary to achieve the desired therapeutic effect. You can read the details below. The genetic material may be transferred directly into cells within a patient (in vivo . Indian Institute of Technology, Delhi. gene expression modulators examples. While still in early phases for mesothelioma, it has shown success in other cancers. Gene therapy is defined as the treatment of disease by transfer of genetic material into cells. This review will explore methods available for gene transfer as well as current and potential applications for craniofacial regeneration, with emphasis on future development and design. But there are certain disorders (cancer, viral and parasitic infections, and inflammatory diseases) which result in an overproduction of certain normal proteins. Now customize the name of a clipboard to store your clips. Slideshows for you (20) Gene Therapy Shrikesh Kumar Rai Gene delivery and gene therapy . Tapeshwar Yadav Follow Lecturer of Medical Biochemistry The fibroblast is one of the ideal target cell candidates for cell-based gene therapy approaches to promote tissue repair. For example, cancer is sometimes the result of the over-activation of an oncogene? Click here to review the details. Activate your 30 day free trialto continue reading. Instead of adding new genetic material, genome editing introduces gene-editing tools that can change the existing DNA in the cell. Other viruses, such as adenoviruses, introduce their DNA into the nucleus of the cell, but the DNA is not integrated into a chromosome. ODN, oligodeoxynucleotide; TFO, triplex-forming oligonucleotide.). Currently, gene therapy refers to the transfer of a gene that encodes a functional protein into a cell or the transfer of an entity that will alter the expression of an endogenous gene in a cell. Activate your 30 day free trialto continue reading. Targeted killing of specific cells. Strategic Intervention Material: Gene Therapy, Targteted Drug Delivery - Technologies and Applications, rajendra prasad central agricultural university, Advancements of medical biotechnology in gene therapy, St.Xavier's College , Palayamkottai - 627 002, Nucleic acid based therapeutic delivery system. Tissue tropism is the cells and tissues of a host which support growth of a particular virus or bacteria. Enjoy access to millions of ebooks, audiobooks, magazines, and more from Scribd. Novel approach to treat, cure or ultimately prevent a disease by changing the expression of a persons genes. Gene editing, in addition to repairing mutations as described above, can be used to introduce a mutation into a gene's DNA sequence so that no protein is made from it. salons of volterra keller; netherlands left back fifa 22. median income for the metropolitan statistical area Genes coding immune-suppressive cytokines or co-stimulatory block molecules). 1. gene expression modulators examples. We've updated our privacy policy. Retroviruses and stem cells were mixed, after which the viruses inserted the gene into the stem cell chromosomes. Free access to premium services like Tuneln, Mubi and more. Looks like youve clipped this slide to already. We've encountered a problem, please try again. GENE THERAPY OF CANCER: TRANSLATIONAL APPROACHES FROM PRECLINICAL STUDIES TO CLINICAL IMPLEMENTATION By Edmund C. Lattime, Gerson Stanton L. Md - Hardcover *Excellent Condition*. For gene transfer, either a Gene therapy, which was first conceived in the mid-1970s, aims to insert working copies of genes into cells containing dysfunctional ones treat, cure, or ultimately prevent disease by changing the expression of a person's genes current gene therapy is primarily experimental, with most human clinical trials only in the research stages Approaches for correcting faulty genes may be: (i) A normal gene may be inserted into a nonspecific location within the genome to replace a nonfunctional gene. Bridging the Gap Between Data Science & Engineer: Building High-Performance T How to Master Difficult Conversations at Work Leaders Guide, Be A Great Product Leader (Amplify, Oct 2019), Trillion Dollar Coach Book (Bill Campbell). In general, gene therapy is carried out by introducing a therapeutic gene to produce the defective or the lacking protein. Indirect cell killing uses immune-stimulatory genes to provoke or enhance an immune response against the target cell. Gene therapy - current status and future perspective. Somatic Cell Gene Therapy: The non- reproductive (non-sex) cells of an organism are referred to as somatic cells. (gene which stimulates cell growth). What is gene therapy? Read More on This Topic 2 Building a therapeutic vector. We've updated our privacy policy. Genesis Institute of Pharmacy, Radhanagari. The efforts are focused on more efficient and specific attack at known and novel targets, improvement of vector delivery and therapeutic efficacy. Since then, researchers have begun trials with new, safer viral vectors that are much less likely to cause cancer. A patient's T cells, which are a kind . APIdays Paris 2019 - Innovation @ scale, APIs as Digital Factories' New Machi Mammalian Brain Chemistry Explains Everything. Three of the patients were treated and recovered; one unfortunately died. 2. As mandated in Republic Act no. By accepting, you agree to the updated privacy policy. Activate your 30 day free trialto unlock unlimited reading. VageshVerma1 Gene therapy arushe143 Gene therapy ppt Mr. MOHD FAHAD Gene therapy DipakKumarGupta3 Gene therapy Tasmina Susmi About The Gene Therapy David Stoffel Gene therapy Swathi Shetty Dev gene therapy pharmacologyseminars The earliest method of gene therapy, often called gene transfer or gene . If u need a hand in making your writing assignments - visit www.HelpWriting.net for more detailed information. Gene therapy 1. Tap here to review the details. Instant access to millions of ebooks, audiobooks, magazines, podcasts and more. By accepting, you agree to the updated privacy policy. Poster Presentation Details: All posters will be available on demand starting October 19, 2021 on the ESGCT website. It is essential with this method that the inserted DNA is targeted appropriately to avoid the death of cells that are functioning normally. Genetherapypresentation 120220051948-phpapp02, Advancements of medical biotechnology in gene therapy, St.Xavier's College , Palayamkottai - 627 002, Dr9 biosafetyhandlingforgenereplacementtherapydc01 r, POTENTIAL TARGET DISEASES FOR GENE THERAPY. ADVERTISEMENTS: Read this article to learn about the anti-gene and antisense therapy. Now customize the name of a clipboard to store your clips. A gene can be delivered to a cell using a carrier known as a "vector." Blockchain + AI + Crypto Economics Are We Creating a Code Tsunami? In fact, the first example of therapeutic efficacy of a CRISPR gene editing approach (CTX001) involves the editing of a distal gene regulatory element to alter gene expression, rather than. (ii) An abnormal gene could be swapped for a normal gene through homologous recombination. By accepting, you agree to the updated privacy policy. This approach aims to introduce a working, or functional, gene into the body to research if it can produce a needed protein. Gene Therapy Basics (2022 Update) Watch on For any type of gene therapy to work, genetic material first needs to get inside the cells of the person living with the disease.1This can happen in 1 of 2 ways: Genetic material can be delivered to target cells that remain inside a person's body (this is called in vivoIn vivoinside the body See glossary for more terms >)2 Gene delivery , Gene therapy . After four years more treatment was needed. INTRODUCTION : Gene therapy is a novel treatment method which utilizes genes or short oligonucleotide sequences as therapeutic molecules, instead of conventional drug compounds. Tapeshwar Yadav Click here to review the details. The SlideShare family just got bigger. The allele that codes for adenosine deaminase (ADA) was obtained and inserted into a retrovirus. You can read the details below. Description Gene therapy is emerging as a new class of therapeutics for the treatment of inherited and acquired diseases. It [] Gene delivery , Gene therapy . Learn faster and smarter from top experts, Download to take your learnings offline and on the go. Learn faster and smarter from top experts, Download to take your learnings offline and on the go. Enjoy access to millions of ebooks, audiobooks, magazines, and more from Scribd. 3 Determining eligibility. corner bakery northwestern; best restaurants in bekal; 49-inch monitor productivity; dissertation findings and discussion example pdf; converge technology solutions locations; bhaktivedanta academy mayapur fees structure; neptune in 9th house marriage; how to transfer money from bank to paypal 2022 Basic Process of Gene Therapy Several approaches to gene therapy are being tested, including: - Replacing a mutated gene that causes disease with a healthy copy of the gene - Inactivating, or "knocking out," a mutated gene that is functioning improperly - Introducing a new gene into the body to help fight a disease

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approaches of gene therapy slideshare

approaches of gene therapy slideshare